Centro around Sol is the first-visit base: walkable, but noisy
Barrio de las Letras puts the Prado, Reina Sofía and Thyssen close
Malasaña has the best food per step; louder at weekends
La Latina is the tapas heartland; the Rastro fills Sunday mornings
Salamanca is the quiet choice, about 20 minutes on foot from Sol
Avoid a street-facing room on Gran Vía: traffic runs all night
Madrid has no tourist tax; all nine areas compared in the guide