
Stay in Centro or around Sol on a first visit to Madrid — the museums, the old city and the metro hub are all within walking distance. Malasaña is the better base if eating well matters more than being in the exact middle, and Salamanca is where to go if you want quiet.
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Centro, around Sol or between Sol and Plaza Mayor. Everything is walkable from there and the metro converges under it. Accept that it is noisy.
It is the quietest and best kept of the central districts, and the furthest from the evening. Good for a calm trip, less good if you want to walk home from dinner at midnight.